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KMID : 0043320150380010042
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Archives of Pharmacal Research
2015 Volume.38 No. 1 p.42 ~ p.51
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Design of phosphated cross-linked microspheres of bael fruit gum as a biodegradable carrier
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Mahammed Nawaz
Gowda D. V.
Deshpande Rohan D.
Thirumaleshwar Shailesh
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Abstract
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Present work was aimed at designing of phosphated cross-linked microspheres of bael fruit gum (BFG) by emulsification method using sodium-tri-meta phosphate as a cross-linking agent for treatment of colon cancer using 5-fluorouracil as model drug. Stirring speed was found to be 1,000 rpm for about 5 h to be optimal to obtain reproducible microspheres. It was found that there is an increase in particle size as polymer concentration is increased whereas a reduction in particle size was observed as there is increase in stirring speed. Cross-linked BFG microspheres were successfully prepared by emulsification method. Optimum surfactant concentration was found to be 2 % w/w. Scanning electron microscopy studies showed that the drug-loaded microspheres were non-aggregated and in spherical shape. Differential scanning calorimetry and Fourier transform infrared-spectroscopy studies showed that drug and excipients are compatible. Release studies showed that drug release was more profound in cecal medium induced with enzymes causing degradation of the cross linked BFG than that of the release showed in simulated intestinal fluid. Stability studies showed that there were no significant changes in the drug content and physical appearance of microspheres.
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KEYWORD
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Bael fruit gum (BFG), Sodium tri-metaphosphate (STMP), Cross-linked microspheres, Colon cancer, 5-Fluorouracil (5-FU)
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